Jake Ruzevick, M.D.

Jake's portrait
Job Title
Resident, PGY-7
Biography

Jacob was born and raised in San Diego, California. He completed his undergraduate training at the Massachusetts Institute of Technology. He attended the Johns Hopkins University School of Medicine where he earned his MD in 2014. While at Johns Hopkins, he also spent 1 year in the lab of Dr. Michael Lim where he completed a Doris Duke Clinical Research Fellowship focusing on immunotherapy for primary brain tumors. Outside of residency, Jacob enjoys playing golf, tennis, running, and cycling around the Seattle area. 

Select awards and honors:

2016   Codman Neuro Resident Travel Grant, University of Washington, Seattle, Washington.

2013   Henry Strong Denison Research Scholar, Johns Hopkins University School of Medicine, Baltimore, Maryland.

2012   Harvey Cushing Medical Student Research Award, Johns Hopkins University School of Medicine, Department of Neurological Surgery, Baltimore, Maryland.

2012   Harold Lamport Research Scholar, Johns Hopkins University School of Medicine, Baltimore, Maryland.

2011   Doris Duke Charitable Foundation Clinical Research Fellowship, Johns Hopkins University School of Medicine, Baltimore, Maryland.

2011   Alpha Omega Alpha Carolyn L. Kuckein Medical Student Research Fellowship Award, Johns Hopkins University School of Medicine, Baltimore, Maryland.

2010   Dean’s Research Funding, Johns Hopkins University School of Medicine, Baltimore, Maryland.

2009   Walle J.H. Nauta Award for Undergraduate Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

2009   NCAA post-graduate scholarship, Massachusetts Institute of Technology, Cambridge, Massachusetts.

2008   MIT Mobility Laboratory International Summer Grant, Massachusetts Institute of Technology, Cambridge, Massachusetts.

2008   MIT Undergraduate Research Opportunity Grant, Massachusetts Institute of Technology, Cambridge, Massachusetts.

2007   Visiting Student Research Fellowship, San Diego Neurosciences Institute, San Diego, California.

2006   MIT Undergraduate Research Opportunity Grant, Massachusetts Institute of Technology, Cambridge, Massachusetts.

 

Clinical Interest

Neuro-Oncology, Spine

Education

Undergraduate Education

Massachusetts Institute of Technology

Medical Education

Johns Hopkins University

Internship

University of Washington

Contact Information

 

Publications
  1. Jackson C, Ruzevick J, Phallen J, Belcaid Z, Lim M. Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment. Clinical and Developmental Immunology. 2011 Oct; 2011(2011): 1-20. PMID: 22190972.

 

  1. Pradilla G, Garzon-Muvdi T, Ruzevick J, Bender M, Edwards L, Momin E, Thompson R, Tamargo R. Systemic L-citrulline prevents cerebral vasospasm in haptoglobin 2-2 transgenic mice after subarachnoid hemorrhage. Neurosurgery. 2012 Mar; 70(3): 747-756. PMID: 21915076.

 

  1. Ruzevick J, Jackson C, Phallen J, Lim M. Clinical trials with immunotherapy for high-grade glioma. Neurosurg Clin N Am. 2012 Jul; 23(3): 459-70. PMID: 22748658.

 

  1. Jackson C, Ruzevick J, Amin A, Lim M. Potential role for STAT3 inhibitors in glioblastoma. Neurosurg Clin N Am. 2012 Jul; 23(3): 379-89. PMID: 22748651.

 

  1. See A, Han J, Phallen J, Binder Z, Gallia G, Pan F, Jinasena D, Jackson C, Belcaid Z, Jeong S, Gottschalk C, Zeng J, Ruzevick J, Nicholas S, Kim Y, Albesiano E, Pardoll D, Lim M. The role of STAT3 activation in modulating the immune microenvironment of GBM. J Neurooncol. 2012 Dec; 110(3): 359-368. PMID: 23096132.

 

  1. Ruzevick J, Jackson C, Pradilla G, Garzon-Muvdi T, Tamargo R. Aneurysm formation in proinflammatory, transgenic haptoglobin 2-2 mice. Neurosurgery. 2013 Jan; 72(1): 70-76. PMID: 23096414.

 

  1. Wolf A, Batra S, Bortoletto P, Ruzevick J, Bettegowda C, Coy S, Amendola B, Blach L, Kleinberg L, Rigamonti D. Stereotactic radiosurgery in treatment of cerebral metastases: histological differences in predictors of survival. Cureus.com. Published January 24, 2013.

 

  1. Jackson C, Ruzevick J, Brem H, Lim M. Vaccine strategies for glioblastoma: progress and future directions. Immunotherapy. 2013 Feb; 5(2): 155-67. PMID: 23413907.

 

  1. Ruzevick J, Olivi A, Westra WH. Metastatic squamous cell carcinoma to the brain: an unrecognized pattern of distant spread in patients with HPV-related head and neck cancer. J Neurooncol. 2013 May; 112(3): 449-454. PMID: 23408186.

 

  1. Zeng J, See A, Phallen J, Jackson C, Belcaid Z, Ruzevick J, Durham N, Meyer C, Harris T, Albesiano E, Pradilla G, Ford E, Wong J, Hammers H, Mathios D, Tyler B, Brem H, Tran P, Pardoll D, Drake C, Lim M. Anti-PD-1 blockade and stereotactic radiation produce long term survival in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys. 2013 June 1; 86(2): 343-349. PMID: 23462419.

 

  1. Nicholas S, Mathios D, Ruzevick J, Jackson C, Yang I, Lim M. Current trends in glioblastoma multiforme treatment: radiation therapy and immune checkpoint inhibitors. BTRT. 2013 April; 1(1): 2-8. PMID: 24904882

 

  1. Garzon-Muvdi T, Pradilla G, Ruzevick J, Bender M, Edwards L, Grossman R, Zhao M, Rudek M, Riggins G, Levy A, Tamargo R. Inhibition of experimental cerebral vasospasm in a murine subarachnoid hemorrhage model using S-4-Carboxyphenylgicine (S-4-CGP), a metabotropic glutamate receptor antagonist. Neurosurgery. 2013 Oct; 73(4): 710-728. PMID: 23842553.

 

  1. Siu IM, Ruzevick J, Zhao Q, Connis N, Burger P, Hann C, Gallia G. Erlotinib inhibits growth in a patient-derived chordoma xenograft. PLoS ONE. 2013 Nov; 8(11)e78895. PMID: 24260133.

 

  1. Ruzevick J, Kleinberg L, and Rigamonti D. Imaging changes following stereotactic radiosurgery for metastatic intracranial tumors: differentiating pseudoprogression from tumor recurrence and its effect on clinical practice. Neurosurgical Review. 2014 Apr; 37(2):193-201. PMID: 24233257.

 

  1. Ruzevick J, Nicholas S, Redmond K, Kleinberg L, Lipson E, and Lim M. Case Report: A patient with HIV treated with ipilimumab and stereotactic radiosurgery for melanoma metastases to the brain. Case Reports in Oncological Medicine. 2013; 2013:946392. PMID: 24383025.

 

  1. Kim J, Patel M, Ruzevick J, Jackson C, Lim M. STAT3 activation in glioblastoma: biochemical and therapeutic implications. Cancers. 2014 Feb 10;6(1): 376-395. PMID: 24518612.

 

  1. Wicks R, Huang Y, Zhang K, Zhao M, Tyler B, Suk I, Hwang L, Ruzevick J, Jallo G, Brem H, Pradilla G, Kang J. Extravascular optical coherence tomography: evaluation of carotid artery atherosclerosis and pravastatin therapy in the apolipoprotein E deficient mouse. Stroke. 2014 Apr; 45(4): 1123-1130. PMID: 24627118.

 

  1. Walker A, Ruzevick J, Malayeri A, Rigamonti D, Lim M, Redmond K, Kleinberg L. Postradiation imaging changes in the CNS: how can we differentiate between treatment effect and disease progression. Future Oncology. 2014 May; 10(7): 1277-1297. PMID: 24947265.

 

  1. Belcaid Z, Phallen J, Zeng J, See A, Mathios D, Gottschalk C, Nicholas S, Kellet M, Ruzevick J, Jackson C, Albesiano E, Durham N, Ye X, Tran P, Tyler B, Wong J, Brem H, Pardoll D, Drake C, Lim M. Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. PLoS One. 2014 Jul; 9(7): e101764. PMID: 25013914.

 

  1. Patel M, Kim J, Ruzevick J, Li G, Lim M. The future of glioblastoma therapy: synergism of standard of care and immunotherapy. Cancers. 2014 Sep; 6(4): 1953-1985. PMID: 25268164.

 

  1. Patel M, Ruzevick J, Lim M. Management of cerebral brain metastases. Curr Surg Rep. 2014 Oct; 2(74).

 

  1. Mathios D, Ruzevick J, Jackson C, Xu H, Shah S, Taube J, Burger P, Quinones-Hinojosa A, Pardoll A, Lim M. PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment. J Neurooncol. 2014 Oct 28. PMID: 25349132.

 

  1. Salmasi V, Schiavi A, Binder Z, Ruzevick, J, Orr B, Burger P, Ball D, Blitz A, Koch W, Ishii M, Gallia G. Intraoperative hypertensive crisis due to a catecholamine-secreting esthesioneuroblastoma. Head Neck. 2014 Oct 28. PMID: 25352487.

 

  1. Ruzevick J, Raza S, Recinos P, Chaichana K, Pradilla G, Kim J, Olivi A, Weingart J, Evans J, Quinones-Hinojosa A, Lim M. Technical Note: Orbitozygomatic craniotomy using an ultrasonic osteotome for precise osteotomies. Clinical Neurology and Neurosurgery. 2015 Apr 13; 134: 24-27. PMID: 25935127.

 

  1. Patel MA, Kim JE, Ruzevick J, Lim M. Present and future of immune checkpoint blockade: Monotherapy to adjuvant approaches. World J Immunol 2014; In press

 

  1. Theodros D, Patel M, Ruzevick J, Bettegowda C. Pituitary adenomas: historical perspective, surgical management, and future directions. CNS Oncology; 2015;4(6): 411-429. PMID: 26497533.

 

  1. Jackson C, Ceccato C, Nirschl C, Durham N, Ruzevick J, Alme A, Francica B, Yingling J, Dubensky T, Lauer P, Brockstedt D, Baxi E, Calabresi P, Pardo-Villamizar C, Brem H, Pardoll D, Lim M, Drake C. Systemic tolerance mediated by CNS tumors is reversed by combined radiotherapy and vaccination. Clinical Cancer Research, 2016 Mar 1; 22(5): 1161-72. PMID: 26490306.

 

  1. Kim E, Kim J, Patel M, Mangraviti A, Ruzevick J, Lim M. Immune checkpoint modulators: an emerging anticancer armamentarium. Journal of Immunology Research; 2016; 2016:4683607. PMID: 26881264.

 

  1. Ruzevick J, Koh EK, Gonzalez-Cuyar L, Cimino P, Moe K, Wright L, Failor R, Ferreira M. Clival paragangliomas: a report of two cases involving the midline skull base and review of the literature. J Neurooncol. 2017 May 132(3): 473-478. PMID: 28299533

 

  1. Mrugala M, Ruzevick J, Zlomanczuk P, Lukas R. Tumor treating fields in neuro-oncological practice. Curr Oncol Rep. 2017 Aug; 19(8) 53 PMID: 28664468

 

  1. Ruzevick J, Wagner T, Hofstetter C. Periprostetic osteolysis after 2 level cervical disc arthroplasty featuring artificial nucleus. Journal of Spine. In print

     
  2. Sen R, White-Dzuro G, Ruzevick J, Kim C, Witt J, Telfeian A, Wang M, Hofstetter C. Intra- and peri-operative complications associated with endoscopic spine surgery: a multi-institutional study. World Neurosurg. 2018 Sept; S1878-8750(18)32029-1 PMID: 30213674 

     
  3. Williams J, Buckley R, Oushy S, Ruzevick J, Chesnut RM. Reversible, position-dependent midbrain compression in a patient with spontaneous intracranial hypotension. World Neurosurg. 2019 Jul 16; 130: 293-297. PMID: 31323415  

 

 

Book Chapters

  1. Ruzevick J, Lim M. Technology and techniques of cranial radiation. Handbook of Radiosurgery in CNS Disease. Eds. M Lim, W Hsu, D Rigamonti, and L Kleinberg. New York, NY: Demos Medical Publishing, Chapter 2: 13 – 25, 2013.

 

  1. Ruzevick J, Batra S, Rigamonti D. Radiosurgery for vestibular schwannomas. Handbook of Radiosurgery in CNS Disease. Eds. M Lim, W Hsu, D Rigamonti, and L Kleinberg. New York, NY: Demos Medical Publishing, Chapter 5: 83 – 91, 2013.

 

  1. Ruzevick J and Kleinberg L. Imaging changes following radiosurgery for metastatic intracranial tumors: a review of differentiating radiation effects from tumor recurrence. Handbook of Radiosurgery in CNS Disease. Eds. M Lim, W Hsu, D Rigamonti, and L Kleinberg. New York, NY: Demos Medical Publishing, Chapter 6: 111 – 120, 2013.

 

  1. Ruzevick J, Batra S, Lim M, Rigamonti D. Radiosurgery for arteriovenous malformations. Handbook of Radiosurgery in CNS Disease. Eds. M Lim, W Hsu, D Rigamonti, and L Kleinberg. New York, NY: Demos Medical Publishing, Chapter 7: 123 – 135, 2013.

 

  1. Ruzevick J, Raza S, Quinones-Hinojosa A. The role of surgery in the management of skull base chordomas. Controversies in Neuro-Oncology. Eds. A Quinones-Hinojosa and S Raza. New York, NY: Thieme Medical Publishing, Chapter 45: 433-441, 2013.

 

  1. Ruzevick J and Mrugala M. Alternating electric fields in clinical practice. Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications. Ed. E Wong. New York, NY: Springer Publishing.

 

  1. Ruzevick J, White-Dzuro G, Kim L, Levitt M, Ferreira M. Intracranial arteriovenous malformations. Management of Head and Neck Vascular Abnormalities. Ed: J Perkins and K Balakrishnan. New York, NY: Springer Publishing.

     
  2. Ruzevick J and Ferreira M. Torcula meningioma. Skull base tumor: approach strategies. Ed: W Jean. New York, NY, Thieme Publishing